time for a pro to chime-in.
first, you dont say if it dies when you run it, or when you >use< it.
UMDgen 4.0 has a bug that makes it crash if you save an iso with a very large number of files.
other than that, it uses a lot of 32bit DLL's - is your o.s. a 64bit one?
kernel32.dll
user32.dll...