Seeking advice on what I should do

a college degree isn't for everyone. just because you haven't got it yet doesn't mean you are doing bad. heck, some people only finished highschool but have a job to support themselves. Volunteering is very important. not only to look good to employeers but to make connections, gain experience and feel good about yourself. by getting out more, the better chance at meeting more people and making friends. who knows it may become something more than friends.
i believe, life is what you make it. so make it happiness. do what you feel you should do and im sure you won't go wrong.

"I can't due to family restraints"
Are those family restraints your kids, kid siblings without parents or seriously dependent upon you with no state support option?

If not then the phrase "you can choose your friends but you can't choose your family" comes into play. Most usually draw other meanings from it but as you did not pick them there is no shame in saying "fuck it, I am done". Obviously if you can reasonably avoid leaving someone in the lurch then maybe do that but it is your life to live.

"reliable transportation"
Is moving somewhere where your feet or a pushbike are viable options an option, if they are not already?

"without a skill"
If you have time to volunteer and seemingly could hack it at college/uni beforehand then you surely have time to do this internet learning lark. I know people love paper but you can still get places with skills alone.
Likewise it is harder, often considerably so, but if you are sound of mind and body there are still more manual labour and semi skilled trades out there you can pick up and do OK from. If you are really good you might even get on the job training/day release to go to a course (building trades and occasionally air con type jobs do this over there, though I am not sure how much AC is in CT compared to more southern states and what might be there might be more specialist IT stuff).

"Has anyone pushed the reset button before with life?"
Myself? No. Plenty of friends have at all ages though and while you will hear it at every age (at least until science cures us of that problem) many would have loved to have done that in their mid 20s. Best years? You heal slower it seems, and maybe you get the start of some aches and pains, but ageing does not kick in for a good while yet.

Now you're making me feel old at 25.
Keep looking ahead and try to (metaphorically) get the next bus out.
There's no point dwelling on mistakes as if you did, you wouldn't do anything of worth, learn from them and attempt to do what you want to do, it doesn't need to be academic, just something you enjoy and know will get you independence from what seems to be an exploitative family.

I've never pushed the reset button, but I know many who have, you won't know until you try and if doesn't work out try and try again.

I'm 34, and I can't stress enough how important it is to make YOURSELF happy, above anything else in life. What do you do for a living? Maybe you need to change your daily routine drastically, like 90% fresh or more.

You know those people who get into a full family life with marriage, kids, pets, loans, mortgages, etc,? When there's a divorce, one person usually has to restart everything, with the challenge of balancing their emotions, children, money, etc,. It's tough, but people do it. Some more than others.

Try to think of what you'd really want to do for the next decade or think of what you absolutely do not want to do ever again. I think you're better off learning to work from home or take a look into medical coding and billing. Even if it isn't option #1, it's a career that will be in demand and sustain you. It does require that you make an investment, but it'll pay off and you'll be able to work all around the U.S.

Alternatively, you could look into T.E.S.L. certifications. You'd literally be paid to do what you've been doing for the past 22+ years. It is a job, so don't think it'll be a magical escape to a foreign country, getting paid to talk to people who want to talk to you. It has its own problems, but it is a way to enrich your life for a year or more doing something you've got experience in.

Personally, I'd take a look at what it is that makes you "truly miserable every single time I open my eyes in the morning." because you might find there's a deeper issue when it's too late and you've got a wife, kids, house, pets, bank accounts, and have to start life over again.