There is no concrete evidence of what the CPU/Memory/Storage Space end result will be, as that will be subject to change over the next 6 months or so.
Anyway from these supposed specifications:
The CPU: IBM Power Architecture-based multi-core 45 nm microprocessor is likely to be comparable to the 360's but with much high clock speeds and better cache. Comparing to PC hardware it would be like a modified AMD Phenom Black Edition Triple Core clocked at around 3-3.4GHz. I can almost guarantee it wont be Quad core as it wont be needed.
Main Memory at a minimum of 512MB, i'd hope for DDR3! Possibly 1GB although it perhaps wont be needed as the console main take is just to run a game with a couple of services running in the background.
Regarding the video memory i'm assuming it will use ultra fast GDDR5 and mostly be a HD4850 v 4890 result as those are the R700 families top cards. The video memory has to be a minimum of 512MB, but from what i gather and expect from knowledge it would need to be 1GB if they want to run high resolutions not silly low res + upscaling. Not only that it will probably support a minimum of 4-8XAA/QSAA and perhaps x8 and in some games x16 Anisotropic filtering. Not only that the video memory is having to output the video, process the video, scale it. Handle all textures/filtering/shadows etc so anything less than 1GB could cause problems and it would be bottlenecking itself. I would expect all games to run at 60+fps, and not suffer like the PS3's 30fps aswell as the 360's changeable 30 - 60fps. The hardware will definitely be capable of it, so hopefully developers are assigned to optimize the game to a extreme extent to impress Nintendo and it's users!
Regarding storage, one would expect Nintendo to release variable models with internal high capacity storage just like Sony/Microsoft consoles. Or perhaps just 1 alternative a 250GB version. Eitherway all models will use a high speed flash drive system probably around 8GB for it's file system. I'm sure we all would prefer to run our most used games off the HDD rather than the disk although you'd need the disk in to play it for security purposes.
My worries:
I hope the GPU chip is a "heavily" modified HD4850 or HD4890 with atleast 512 - 1GB of GDDR3 or GDDR5 ram. It's bound to be based on the 4850 since that's the average ATI R700 family chip, which is on par to a NVIDIA 9800GTX. Eitherway the GPU chip will be 4 years behind PC, although it's still kinda powerful.
What worries me is the resolution, hope resolutions are at the correct value, i don't want rubbish upscaled 1000x600 and the likes which most PS3/360's use.
Nintendo should create their own in game engine or atleast get a major 3rd party developer to do so.
Since it will be backwards compatible to Wii games, i'm assuming online play would still work and parts of the machine would hibernate till returned to the main menu. With services still running in the background like downloading/online friends lists, messages etc.
I also hope that they have a up-scaling addition that will run on all Wii games, this is not difficult for them!
I cant understand how the tablet controller will work, perhaps it has a separate less powered graphics chip inside it too? and then the main graphics chip counter acts with the tablet to produce high quality displays. This is the most striking area that i'm interested in.
Overall Wii U will be a pleasant experience, it's a impressive console for the price and that it would probably cost around £220 with no HDD and £300 for it's highest capacity hard drive model.
Wii Motion + is still the best option for playing most first person shooters, i just hope they have a better sensor bar so the cursor doesn't drift off to god knows where.
What i believe will be the case, i recon something like Battlefield 3 will be released on the console but perhaps it will have a wireless controller that comes with it, but would probably be around £45 to buy the game (with the controller). I'm pretty sure certain first person shooters would need a true analogue controller similar to the 360 pad (which in my opinion is the best pad ever).
And the biggest problem I see here is that when the console is released, it is 3-4years behind PC. I mean take the AMD ATI GPU series, we are in the 6000 series, not the 4000 which the Wii U will be using. So when people play it, they are gunna be like zOMG have ya seem the gfx?!!!! So again, Nintendo are going to release an outdated console. Mind you the reason for this as we all know is production costs and consumer cost. Eitherway it's still a reasonably impressive console.