TL;DR the answer is yes. But the problem is getting every Skylander as a .SPYRO file and swapping every time you wanted to use another. So if there is a way it would have to swap those files in the save. Could a hack allow this to happen while the game is still running? If not, how hard is it to get a utility to swap Skylanders out? Online I've only seen the .sav going around with 2 of the in-box figures. If there was an archive of all of them that would be very much appreciated for archival sake.