Funny how you should say that The Powerpuff Girls is a girl's cartoon. I actually watched it religiously myself, way back in the day!
This may come to shock you, but the same person who made The Powerpuff Girls also made My Little Pony: Friendship is Magic.
Then again, having the same producer doesn't mean it's the same show. Obviously, it's a lot less action-oriented than its predecessor, with an eponymously (no, it's not a pun...) bigger focus on "the magic of friendship", and it's on a completely other channel (which means it's a different demographic
).
One point I think you dodge, by pointing at Cartoon Network's demographical shift ("reality shows"), is the fact that a lot of people mention the similarities between the older shows from back in the day to this show about ponies. I really don't have a say here, since I didn't exactly grow up on cartoons. But I know you're older than myself, and could probably make a more educated guess than me.
I'm also going to avoid going in the direction of what constitutes as a girls show. It's more a kids show, since the lines are more blurred here than what they seem, and the gender issue is delicate.