ok, good question:
"brickblocking" - this means "erasing the update on the disc". The launchers don't read the update partition at all, so this is not needed, PERIOD.
wiifrii'ing - you may or may not use discs from different regions, for these, you MAY have to adjust settings on a game-by-game basis. For me, lets so I have a semi-tricky PAL game for my NTSC wii (AND lets pretend I actually use launchers instead of my chip)...I put it in, load up...
....Gamma, and as soon as I click "start" I hold the 1(one) button [with the disc already in the drive by the way] now I should have some options, I go into the config options (forget what that little sub-menu is actually called, the non-rebooter one) and select "Force NTSC" and maybe "Force English Language". then I scroll down, hit A to go back, and select run disc at the main menu or whatever it says.
....Softchip has similar options "Use System Region to determine disc Video output" or something, and "Force Launguage: English"
for most instances, if its gonna work, this will be enough.
Ive only had one case where a PAL game would work after running through wiifrii with similar choices, but not just regularly through the channel, usually if a game from the opposing video signal gives you trouble a couple times, its just not gonna work no matter what....examples for NTSC folks like me include DBZ:BT3 and Gravity PAL versions.
scrubbed discs and trucha-signed discs (not the same fyi) should work fine as well, if you dont know anything about them, dont worry you dont need to.
thats already more than I should have spoonfed you, find out more on your own.
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