Considering the rampant piracy on the Wii, DS, and 3DS, and the fact that they all remained successful systems. My gut says no, the scene that pirates will never seem to be large enough to offset the majority that don't pirate for their consoles. If a system is a success, it seems to stay a success despite the piracy, I can't think of a situation within the industry where a successful system died once (and because) piracy became a thing for it.