I'm guessing there will be new trailers for some 3DS games (Luigi's Mansion 2, Animal Crossing, and Paper Mario), show off the new eShop system (Buying/browsing games online and by smart phone), show somethings about the WiiU (If they do change the name or change the console design, now would be a good time) but no release date and price, and there's a chance of them announcing the Monster Hunter TriG localization. Also, they'll definitely talk about Kid Icarus, but nothing really shocking/nothing we don't know.